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Models of Seizures and Epilepsy
Author: Asla Pitkänen, Paul Buckmaster, DVM, PhD, Aristea S Galanopoulou, Solomon L. Moshé
Publisher: Academic Press
ISBN: 012804067X
Pages: 1178
Year: 2017-06-14
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Models of Seizures and Epilepsy, Second Edition, is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models to address key questions in the field. The book also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research as well as R&D drug development. Contents include the current spectrum of models available to model different epilepsy syndromes, epilepsy in transgenic animals, comorbidities in models of epilepsy, and novel technologies to study seizures and epilepsies in animals. Provides a comprehensive reference detailing animal models of epilepsy and seizure Offers insights on the use of novel technologies that can be applied in experimental epilepsy research Edited by leading experts in the field that provide not only technical reviews of these models but also conceptual critiques Comments on the strengths and limitations of various models, including their relationship to clinical phenomenology and their value in developing better understanding and treatments
Models of Seizures and Epilepsy
Author: Asla Pitkänen, Philip A. Schwartzkroin, Solomon L. Moshé
Publisher: Elsevier
ISBN: 0080457029
Pages: 712
Year: 2005-10-04
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An understanding of mechanisms underlying seizure disorders depends critically on the insights provided by model systems. In particular with the development of cellular, molecular, and genetic investigative tools, there has been an explosion of basic epilepsy research. Models of Seizures and Epilepsy brings together, for the first time in 30 years, an overview of the most widely-used models of seizures and epilepsy. Chapters cover a broad range of experimental approaches (from in vitro to whole animal preparations), a variety of epileptiform phenomenology (including burst discharges and seizures), and suggestions for model characterization and validation, such as electrographic, morphologic, pharmacologic, and behavioral features. Experts in the field provide not only technical reviews of these models but also conceptual critiques - commenting on the strengths and limitations of these models, their relationship to clinical phenomenology, and their value in developing a better understanding and treatments. Models of Seizures and Epilepsy is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models for addressing key questions in the field. It also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research. The first comprehensive description of animal models of epilepsy since the early 1970's Comprehensive analysis of "What the models model" to guide the selection of each model, and what specific questions it will answer Elegant examples of the use of novel technologies that can be applied in experimental epilepsy research World expert opinions on the clinical relevance of each model
Models of Seizures and Epilepsy
Author: Asla Pitkänen, Solomon L. Mosh, Aristea S. Galanopoulou
Publisher: Academic Press
ISBN: 0128040661
Pages: 1178
Year: 2017-06-16
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Models of Seizures and Epilepsy, Second Edition, is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models to address key questions in the field. The book also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research as well as R&D drug development. Contents include the current spectrum of models available to model different epilepsy syndromes, epilepsy in transgenic animals, comorbidities in models of epilepsy, and novel technologies to study seizures and epilepsies in animals. Provides a comprehensive reference detailing animal models of epilepsy and seizure Offers insights on the use of novel technologies that can be applied in experimental epilepsy research Edited by leading experts in the field that provide not only technical reviews of these models but also conceptual critiques Comments on the strengths and limitations of various models, including their relationship to clinical phenomenology and their value in developing better understanding and treatments
Epileptic Seizures and the EEG
Author: Andrea Varsavsky, Iven Mareels, Mark Cook
Publisher: CRC Press
ISBN: 1439812047
Pages: 370
Year: 2016-04-19
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Analysis of medical data using engineering tools is a rapidly growing area, both in research and in industry, yet few texts exist that address the problem from an interdisciplinary perspective. Epileptic Seizures and the EEG: Measurement, Models, Detection and Prediction brings together biology and engineering practices and identifies the aspects of the field that are most important to the analysis of epilepsy. Analysis of EEG records The book begins by summarizing the physiology and the fundamental ideas behind the measurement, analysis and modeling of the epileptic brain. It introduces the EEG as a measured signal and explains its use in the study of epilepsy. Next, it provides an explanation of the type of brain activity likely to register in EEG measurements, offering quantitative analysis of the populations of neurons that contribute to both scalp and cortical EEG and discussing the limitations and effects that choices made in the recording process have on the data. The book provides an overview of how these EEG records are and have been analyzed in the past, concentrating on the mathematics relevant to the problem of classification of EEG. The authors use these extracted features to differentiate between or classify inter-seizure, pre-seizure and seizure EEG. The challenge of seizure prediction The book focuses on the problem of seizure detection and surveys the physiologically based dynamic models of brain activity. Finally, the book addresses the fundamental question: can seizures be predicted? Through analysis of epileptic activity spanning from 3 hours to 25 years, it is proposed that seizures may be predictable, but the amount of data required is greater than previously thought. Based on the authors’ extensive research, the book concludes by exploring a range of future possibilities in seizure prediction.
Epilepsy Across the Spectrum
Author: Committee on the Public Health Dimensions of the Epilepsies, Board on Health Sciences Policy, Institute of Medicine
Publisher: National Academies Press
ISBN: 0309255074
Pages: 521
Year: 2012-07-13
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Although epilepsy is one of the nation's most common neurological disorders, public understanding of it is limited. Many people do not know the causes of epilepsy or what they should do if they see someone having a seizure. Epilepsy is a complex spectrum of disorders that affects an estimated 2.2 million Americans in a variety of ways, and is characterized by unpredictable seizures that differ in type, cause, and severity. Yet living with epilepsy is about much more than just seizures; the disorder is often defined in practical terms, such as challenges in school, uncertainties about social situations and employment, limitations on driving, and questions about independent living. The Institute of Medicine was asked to examine the public health dimensions of the epilepsies, focusing on public health surveillance and data collection; population and public health research; health policy, health care, and human services; and education for people with the disorder and their families, health care providers, and the public. In Epilepsy Across the Spectrum, the IOM makes recommendations ranging from the expansion of collaborative epilepsy surveillance efforts, to the coordination of public awareness efforts, to the engagement of people with epilepsy and their families in education, dissemination, and advocacy for improved care and services. Taking action across multiple dimensions will improve the lives of people with epilepsy and their families. The realistic, feasible, and action-oriented recommendations in this report can help enable short- and long-term improvements for people with epilepsy. For all epilepsy organizations and advocates, local, state, and federal agencies, researchers, health care professionals, people with epilepsy, as well as the public, Epilepsy Across the Spectrum is an essential resource.
Jasper's Basic Mechanisms of the Epilepsies
Author: Jeffrey Noebels, Massimo Avoli, Michael Rogawski, Richard Olsen, Antonio Delgado-Escueta
Publisher: Oxford University Press
ISBN: 0199842590
Pages: 1264
Year: 2012-06-01
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H.H. Jasper, A.A. Ward, A. Pope and H.H. Merritt, chair of the Public Health Service Advisory Committee on the Epilepsies, National Institutes of Health, published the first volume on Basic Mechanisms of the Epilepsies (BME) in 1969. Their ultimate goal was to search for a "better understanding of the epilepsies and seek more rational methods of their prevention and treatment." Since then, basic and clinical researchers in epilepsy have gathered together every decade and a half with these goals in mind -- assessing where epilepsy research has been, what it has accomplished, and where it should go. In 1999, the third volume of BME was named in honor of H.H. Jasper. In line with the enormous expansion in the understanding of basic epilepsy mechanisms over the past four decades, this fourth edition of Jasper's BME is the most ambitious yet. In 90 chapters, the book considers the role of interactions between neurons, synapses, and glia in the initiation, spread and arrest of seizures. It examines mechanisms of excitability, synchronization, seizure susceptibility, and ultimately epileptogenesis. It provides a framework for expanding the epilepsy genome and understanding the complex heredity responsible for common epilepsies as it explores disease mechanisms of ion channelopathies and developmental epilepsy genes. It considers the mechanisms of conditions of epilepsy comorbidities. And, for the first time, this 4th edition describes the current efforts to translate the discoveries in epilepsy disease mechanisms into new therapeutic strategies. This book, considered the 'bible' of basic epilepsy research, is essential for the student, the clinician scientist and all research scientists who conduct laboratory-based experimental epilepsy research using cellular, brain slice and animal models, as well as for those interested in related disciplines of neuronal oscillations, network plasticity, and signaling in brain strucutres that include the cortex, hippocampus, and thalamus. In keeping with the 1969 goals, the book is now of practical importance to the clinical neurologist and epileptologist as the progress of research in molecular genetics and modern efforts to design antiepileptic drugs, cures and repairs in the epilepsies converge and impact clinical care.
Computational Neuroscience in Epilepsy
Author: Ivan Soltesz, Kevin Staley
Publisher: Academic Press
ISBN: 0080559530
Pages: 624
Year: 2011-09-02
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Epilepsy is a neurological disorder that affects millions of patients worldwide and arises from the concurrent action of multiple pathophysiological processes. The power of mathematical analysis and computational modeling is increasingly utilized in basic and clinical epilepsy research to better understand the relative importance of the multi-faceted, seizure-related changes taking place in the brain during an epileptic seizure. This groundbreaking book is designed to synthesize the current ideas and future directions of the emerging discipline of computational epilepsy research. Chapters address relevant basic questions (e.g., neuronal gain control) as well as long-standing, critically important clinical challenges (e.g., seizure prediction). Computational Neuroscience in Epilepsy should be of high interest to a wide range of readers, including undergraduate and graduate students, postdoctoral fellows and faculty working in the fields of basic or clinical neuroscience, epilepsy research, computational modeling and bioengineering. Covers a wide range of topics from molecular to seizure predictions and brain implants to control seizures Contributors are top experts at the forefront of computational epilepsy research Chapter contents are highly relevant to both basic and clinical epilepsy researchers
Encyclopedia of Basic Epilepsy Research
Author:
Publisher: Academic Press
ISBN: 0123739616
Pages: 1832
Year: 2009-05-27
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As a truly translational area of biomedical investigation, epilepsy research spans an extraordinary breadth of subjects and involves virtually every tool that modern neuroscience has at its disposal. The Encyclopedia of Basic Epilepsy Research provides an up to date, comprehensive reference for all epilepsy researchers. With an expert list of authors, the encyclopedia covers the full spectrum of research activities from genes and molecules to animal models and human patients. The encyclopedia's electronic format also provides unparalleled access to frequent updates and additions, while the limited edition print version provides another option for owning this content. The Encyclopedia of Basic Epilepsy Research is an essential resource for researchers of all levels and clinicians who study epilepsy. The only comprehensive reference for basic research and current activities in epilepsy Electronic format provides fast and easy access to updates and additions, with limited print version available as well Contains over 85 articles, all written by experts in epilepsy research
Astrocytes and Epilepsy
Author: Jacqueline A. Hubbard, Devin K. Binder
Publisher: Academic Press
ISBN: 0128026243
Pages: 394
Year: 2016-07-05
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Epilepsy is a devastating group of neurological disorders characterized by periodic and unpredictable seizure activity in the brain. There is a critical need for new drugs and approaches given than at least one-third of all epilepsy patients are not made free of seizures by existing medications and become "medically refractory". Much of epilepsy research has focused on neuronal therapeutic targets, but current antiepileptic drugs often cause severe cognitive, developmental, and behavioral side effects. Recent findings indicate a critical contribution of astrocytes, star-shaped glial cells in the brain, to neuronal and network excitability and seizure activity. Furthermore, many important cellular and molecular changes occur in astrocytes in epileptic tissue in both humans and animal models of epilepsy. The goal of Astrocytes and Epilepsy is to comprehensively review exciting findings linking changes in astrocytes to functional changes responsible for epilepsy for the first time in book format. These insights into astrocyte contribution to seizure susceptibility indicate that astrocytes may represent an important new therapeutic target in the control of epilepsy. Astrocytes and Epilepsy includes background explanatory text on astrocyte morphology and physiology, epilepsy models and syndromes, and evidence from both human tissue studies and animal models linking functional changes in astrocytes to epilepsy. Beautifully labelled diagrams are presented and relevant figures from the literature are reproduced to elucidate key findings and concepts in this rapidly emerging field. Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators as well as neurologists and other specialists caring for patients with epilepsy. Presents the first comprehensive book to synthesize historical and recent research on astrocytes and epilepsy into one coherent volume Provides a great resource on the field of astrocyte biology and astrocyte-neuron interactions Details potential therapeutic targets, including chapters on gap junctions, water and potassium channels, glutamate and adenosine metabolism, and inflammation
Animal Models of Epilepsy
Author: Scott C. Baraban
Publisher: Humana Press
ISBN: 1603272623
Pages: 265
Year: 2009-05-29
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In this book, investigators examine several novel models of epilepsy in mice as well as in genetically tractable "simple" species. This is an ideal guide for scientists who wish to expand our understanding of the pathogenesis of this neurological disorder.
Seizure Prediction in Epilepsy
Author: Björn Schelter, Jens Timmer, Andreas Schulze-Bonhage
Publisher: John Wiley & Sons
ISBN: 3527625208
Pages: 369
Year: 2008-11-21
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Comprising some 30 contributions, experts from around the world present and discuss recent advances related to seizure prediction in epilepsy. The book covers an extraordinarily broad spectrum, starting from modeling epilepsy in single cells or networks of a few cells to precisely-tailored seizure prediction techniques as applied to human data. This unique overview of our current level of knowledge and future perspectives provides theoreticians as well as practitioners, newcomers and experts with an up-to-date survey of developments in this important field of research.
Epilepsy
Author: David W. McCandless
Publisher: Springer Science & Business Media
ISBN: 1461403618
Pages: 532
Year: 2011-11-02
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The present volume is intended to be a synopsis of seizure disorders with a goal of describing key studies in animals and humans. The translation of pertinent findings from animal studies to human studies, and to potential human studies will be emphasized. Specific cogent animal studies/results which deserve exploration in human seizure disorders will be detailed. The current rate of translation is estimated to be from 7‐9 years, and the “success” rate of translation was very recently listed as less than one half. The success rate is defined as results in human studies which were predicted in advance by animal studies. Both the time between animal and human attempts plus the success rate need improvement.
Epilepsy
Author: Jong Rho, Raman Sankar, Carl E. Stafstrom
Publisher: CRC Press
ISBN: 1420085603
Pages: 684
Year: 2010-06-18
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Epilepsy has afflicted humankind throughout recorded history; yet, it is only in the last half-century, that significant progress has been made in our basic understanding of the epileptic brain. Pivotal advances in drug development and surgical techniques, as well as the emergence of innovative approaches such as electrical stimulation of the nervous system, have led to a substantial reduction in the morbidity and mortality of patients with epilepsy. At the same time, remarkable developments in neuroscience have enhanced our understanding of brain structure and function. Epilepsy: Mechanisms, Models, and Translational Perspectives incorporates new translational advances that bring epilepsy therapies from the laboratory bench to the bedside and back again. It brings together the work of more than 70 of the field’s most respected and cutting-edge researchers and clinicians. In 24 chapters, this extraordinarily comprehensive and current work: Offers an overview of the basic anatomic and functional substrates of seizure genesis and considers novel pathogenic concepts that have both emerged and been validated experimentally Examines antiepileptic drug therapy, including the latest on molecular targets Looks at the state of surgical treatments for epilepsy and discusses advances in the fields of structural and functional neuroimaging Reviews the variety of nontraditional therapeutic options, such as the ketogenic diet, the vagus nerve stimulator, immunomodulators, neurosteroids, herbs, and botanicals Investigates neuroendocrine, hormonal, and biobehavioral factors that influence seizure susceptibility—information that can be incorporated into the design of treatment algorithms on an individualized basis Provides a glimpse of what future epilepsy therapies might look like, from novel mechanisms of drug delivery to gene and stem-cell therapies for epilepsy to seizure detection methods, to the ultimate goal of disease prevention. The idea for this book was inspired by the editors’ collective desire to promote bridging of the so-called translational divide—that is, covering innovative treatment strategies based on scientific principles that have yet to be tested rigorously in the clinical setting, but yet may provide practitioners with new and promising approaches toward epilepsy therapeutics.
Seizures
Author: Norman Delanty
Publisher: Springer Science & Business Media
ISBN: 1592590942
Pages: 368
Year: 2001-11-27
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Seizures are frightening events. They frighten the patients who experience them; they frighten those who witness them; they also frighten many physicians who have to deal with them. Most individuals with seizures present to family physicians or to emergency room physicians. However, despite the fact that seizures are among the most common neurological conditions, most general practitioners, family practice specialists, and intemists do not see large numbers of patients with seizures. Given the apoplectic appearance of generalized tonic clonic convulsions, it is not difficult to understand why they arouse such emotional responses in those that experience them, those that witness them, and those whose care is sought for them. Seizures are symptoms of something wrong with the brain. Many different kinds of perturbations in brain anatomy, chemistry, or physiology can produce seizures. For many individuals, seizures occur in the context of an acute illness and will not recur once that illness is treated. These individuals do not have epilepsy. They have transient disturbances in brain function attributable to systemic medical conditions. It is important to recognize these issues, because, first, the seizure may be the initial, or even only, manifestation of the underlying medical problem and this needs to be recognized.
Seizures and Epilepsy
Author: Jerome Engel
Publisher: Oxford University Press
ISBN: 019532854X
Pages: 706
Year: 2013-01-31
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This second edition of Seizures and Epilepsy, written almost a quarter of a century after the ground-breaking first edition, is more than an update: it is a complete revision due to tremendous advances in the field. Our understanding of the fundamental neuronal mechanisms underlying epileptic phenomena, as well as current diagnosis and treatment, have been heavily influenced over the past several decades by seminal neuroscientific developments, particularly the introduction of molecular neurobiology, genetics, and modern neuroimaging. According to the World Health Organization, epilepsy accounts for 1% of the global burden of disease, equivalent to breast cancer in women and lung cancer in men. Among primary disorders of the brain, it is equivalent to depression, dementia, and substance abuse. Singly authored by Jerome Engel, Jr, this must-read from 1989 reasserts itself as a modern classic comprehensive textbook covering a broad range of both basic and clinical epileptology.